The research allows to detect the conditions under which Alzheimer’s disease and other related illnesses appear. Russian News Agency TASS, one of the largest news agencies worldwide, reports on :
Russian scientists have described a mechanism that controls the ability of the human brain to change. This will help to better understand the conditions in which brain function is impaired – for example, in Alzheimer’s disease. The research results have been published in the Science Advances scientific journal, as 海角直播 press service reports.
The researchers have identified the functional nano-architecture of synapses, which enable contacts between nerve cells. The article describes the structure of molecular mechanisms controlling the ability of brain to change along one鈥檚 life. The scientists determine the important role of calcium ions accumulated in 鈥榥ano-tanks鈥�, typical of every synapse, contributing to nerve cells鈥� operation.
When the synapse is triggered, the 鈥榥ano-tanks鈥� is emptied, and then filled up again. The details of such mechanism have remained previously unknown. The studies show that the 鈥榯ank鈥� is strictly oriented in space and retains a kind of a memory vector.
“Alzheimer’s disease is known for the loss of synaptic contacts. For the first time ever, our article describes the molecular mechanism by which the 鈥榥ano-tank鈥� can be filled without the synapses being involved. We assume that learning to control this mechanism can alleviate the symptoms of the disease and preserve memory,”
says Dr. Eduard Korkotyan, co-author, professor at 海角直播 and (Israel).
Learning to control this process, we reduce the consequences of many diseases associated with brain damage.
鈥淚t has been found that nanostructures within thousands of spines, located on the surface of each neuron, are capable of precisely directing calcium gradients that create rapid transients. This happens in milliseconds and less than ten thousandths of a millimeter in space. To explain such processes, we had to apply newly the theory known as statistics of extreme events “,
notes Professor Eduard Korkotyan.
In addition to Professor Eduard Korkotian and graduate student Lilia Kushnireva, the group of researchers, included Kanishka Basnayake (脡cole normale sup茅rieure, , France), David Mazaud (, France), Alexis Bemelmans (CEA Universit茅 Pierre et Marie Curie, 听France), Natalie Ruach (, France) and David Holkman (, France).
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The picture shows calcium (yellow), which is transported from the synapse to the nano-tank (green) thanks to ion pumps (red). Then it moves along the arrows and stands out from the opposite side of the tank through the pore systems (blue). The whole process takes less than 1 millisecond. The tank is about 200 nanometers in size.
